Prognostic significance of pretreatment proliferative activity in adult acute leukemia
نویسندگان
چکیده
منابع مشابه
Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia.
An analysis of 55 adult patients (age > 1 5 yr) with previously untreated acute lymphoblastic leukemia (ALL) was undertaken to correlate presenting clinical features with outcome of treatment. Patients achieving complete remission (CR) were compared to those without CR for the presence or magnitude of 24 pretreatment characteristics. The effect of each characteristic on remission duration and s...
متن کاملRelationship of pretreatment lymphoblast proliferative activity and prognosis in 97 children with acute lymphoblastic leukemia.
We have analyzed the pretreatment 3H-thymidine labeling indices in blood and marrow blast cells from 97 children with acute lymphoblastic leukemia (ALL) and circulating blasts. The median marrow labeling index (LI) was 6.2% (range 0.8%--32.7%) and the median blood LI, 3.2% (range 0.3%--20%). Blood LI was significantly correlated with leukocyte count and rosette-forming (E+) lymphoblasts but not...
متن کاملSignificance of Cross Lineage Antigen Expression in Acute Lymphoblastic Leukemia
Background: Aberrant expression of cross-lineage antigens gives valuable insight into the diagnosis and prognosis of acute leukemia. In countries like India, cytogenetic tests are widely accessible. Exploring the prognostic value of an accessible test is of great importance. Therefore, establishing a population-specific immunophenotype database will enable to design an antibody panel equipped t...
متن کاملPROGNOSTIC VALUE OF MYELOID ANTIGEN EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA
Expression of cell surface molecules associated with lymphoid and myeloid lineage differentiation on the blasts of 53 patients with acute lymphoblastic leukemia (ALL) was investigated. 1.9% of cases were only HLA"7DR+ 7.6% were HLA-DR+, CDI9+ 22.6% were HLA-DR+, CDI9+, CDI0+ 30.2% were HLADR+, CDI9+, CDlO±, CD20+ and 37.7% were HLA-DR±, CD7+, CD5±. Aberrant expression of one or more myeloi...
متن کاملPretreatment flow cytometry of DNA content in adult acute leukemia.
Flow cytometric analyses of bone marrow cellular DNA content were performed in 1 1 5 adult patients with acute leukemia to assess whether and how proliferative activity relates to other disease and host parameters, to antileukemic effect of induction chemotherapy. and to patient prognosis. Eighty previously untreated patients had a smaller S-phase compartment than patients with morphologically ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1977
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197704)39:4<1603::aid-cncr2820390435>3.0.co;2-8